Editorial: Safety of Red Blood Cell Substitutes as Compared to Stored Donor Red Blood Cells
نویسندگان
چکیده
منابع مشابه
Future generations of red blood cell substitutes.
Polyhaemoglobins (PolyHb) and perfluorochemicals are in advanced phase III clinical trials and conjugated haemoglobins in phase II clinical trial. New recombinant human haemoglobin with no vasoactivity is being developed. A soluble macromolecule of PolyHb-catalase-superoxide dismutase is being studied as an oxygen carrier with antioxidant properties. New artificial red blood cells that are more...
متن کاملHemoglobin-based red blood cell substitutes.
Polyhemoglobin is already well into the final stages of clinical trials in humans with one approved for routine clinical use in South Africa. Conjugated hemoglobin is also in ongoing clinical trials. Meanwhile, recombinant Hb has been modified to modulate the effects of nitric oxide. Other systems contain antioxidant enzymes for those clinical applications that may have potential problems relat...
متن کاملRed blood cell substitutes: current status.
The transfusion of allogeneic blood (or plasma or red cells) involves many hoards (see table 1), some of which may be reduced or avoided. For example, the patient's own blood rather than allogeneic blood may be transfused: by 1990 more than 5% of units collected in the USA were of autologous blood [42]. In the United Kingdom, the National Transfusion Service is now, in some regions at least, pr...
متن کاملAlterations in cell surface area and deformability of individual human red blood cells in stored blood
The functionality and viability of stored human red blood cells (RBCs) is an important clinical issue in transfusion. To systematically investigate changes in stored whole blood, the hematological properties of individual RBCs were quantified in blood samples stored for various periods with and without a preservation solution called CPDA-1. With 3-D quantitative phase imaging techniques, the op...
متن کاملElectrophoretic studies of red cell extracts of stored blood.
It has been shown that red cells of blood collected in acid-citrate-dextrose (ACD) undergo changes in their dimensions, osmotic fragility, permeability and metabolism during storage at 4° C (1). Information concerning the effect of storage on the physical and chemical states of soluble red cell proteins, particularly hemoglobin, is not available. Such data may be of interest in view of the mark...
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ژورنال
عنوان ژورنال: Artificial Cells, Blood Substitutes, and Biotechnology
سال: 2008
ISSN: 1073-1199,1532-4184
DOI: 10.1080/10731190701854584